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Methylation changes in the Tau , particularly at CpG dinucleotide sites, have been shown to alter microtubule function, promoting aberrant Tau aggregation and the formation of neurofibrillary tangles (130, 131)

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This observation was further validated by flow cytometry (Fig

Apart from causing cholinergic degeneration, A leads to the disruption of signaling that is involved in long-term potentiation and memory in the hippocampus (15,16)

Chu et al showed that systemic levels of IGF-I can be restored by intravenous delivery of an AAV vector encoding mouse IGF-I(Eb) cDNA, in a streptozotocin (STZ)-induced mouse model of diabetic peripheral neuropathy