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An enzyme called tyrosinase is needed to create melanin (the pigment that causes the brown spots) and while several other skin lightening agents work to inhibit the synthesis of tyrosinase itself (like vitamin C or licorice), arbutin lets tyrosinase be and rather hinders the melanin-forming activity of the enzyme

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442 However, for cholangiocarcinoma (CCA), the second most common type of primary liver cancer, mitochondrial OXPHOS metabolism helps maintain stem-like characteristics in CCA, thereby conferring tumorigenic potential and chemotherapy resistance in vivo