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Teams are working on conjugating LR3 to muscle-specific ligands (integrins, dystroglycan) or neuronal ones (cell-penetrating peptides, blood-brain barrier targeting via transferrin receptor transcytosis) to concentrate trophic action where desired while limiting potentially deleterious systemic effects (hypoglycemia, uncontrolled mitogenesis)

[PubMed] Dringen R

However, these approaches do not directly target the underlying molecular mechanisms of injury, nor do they reliably prevent progression to CKD or end-stage renal disease (ESRD) (Gaut and Liapis 2021

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