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The expression of TNF- and CCL21 is upregulated in the dorsal horn neurons of the spinal cord, while IL-1 and PK-2 levels are increased in the astrocytes of the dorsal horn (Moschetti et al., 2019

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The hypopigmentation associated with PIH that develops after injury, burn, or other inflammatory condition may be permanent if the melanocytes in the area have been severely damaged or destroyed

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