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doi:10.1007/s00228-010-0975-2

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Moreover, serotonin produced in the gut cannot cross the blood-brain barrier, and therefore, does not contribute directly to central neurotransmission

Clin Neuropharmacol 36:103106 Remington R, Lortie JJ, Hoffmann H, Page R, Morrell C, Shea TB (2015) A nutritional formulation for cognitive performance in mild cognitive impairment: a placebo-controlled trial with an open-label extension

Building on this, the potential of ferroptosis-related biomarkers for OA diagnosis and treatment is highlighted, along with proposed therapeutic strategies targeting ferroptosis regulation