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Considering its protective role, the GLX pathway has been studied in many plant species over the past 20 years, and overexpression of enzymes catalyzing the two steps, separately or together, has shown that they confer significant tolerance to several abiotic stresses such as salinity, heavy metals, and drought (reviewed in [167,188])

^ Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure

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