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The contradictory response of glutathione gel in the treatment of melasma in different studies may be attributed to the difference in stability, absorption, penetration of glutathione and affected by the different vehicle (soap, cream, gel or lotion) rather than the efficacy of glutathione itself

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It adds a 13-amino-acid N-terminal extension and an Arg3-to-Glu substitution, and retains the three disulfide bonds essential for structure and receptor binding