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Widely referenced in neurochemical and circadian rhythm research, DSIP is studied for its interaction with central nervous system signalling pathways and stress-response modulation

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For example, a preclinical trial studying CD151, a member of the transmembrane four superfamilies that plays a key role in maintaining vascular stability, showed that its upregulation in the early phases of stroke is able to preserve BBB integrity (239), turning it into a possible therapeutic target