This occurs when receptors receptors for the excitatory neurotransmitter such as the NMDA and AMPA receptors are overactivated. Wikipedia Interestingly, given the low blood flow problems in chronic fatigue syndrome, central nervous system ischemia (low blood flows) increases glutamate levels and contributes to cellular death
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References: Glutathione and Parkinsons Disease: Glutathione metabolism in type 2 diabetes and its relationship with microvascular complications and glycemia Glutathione supplementation improves oxidative damage in experimental colitis Application of Glutathione as Anti-Oxidative and Anti-Aging Drugs Differentiating Sulfur Compounds Sulfa Drugs, Glucosamine Sulfate, Sulfur, and Sulfiting Agents by Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon
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