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Glutathione is naturally produced by the liver and plays a key role in cellular repair, immune function, and the neutralization of harmful free radicals

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As reported by Stanley 15 , GDH Ser441Leu mutant is associated with the HI/HA syndrome and is the result of a substitution from Serine TCG to Leucine TTG codon in the GLUD1 gene that encode the enzyme GDH