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7.2 Alzheimers disease Alzheimers disease (AD) is a prevalent neurodegenerative disorder characterized by -amyloid (A) plaque deposition, tau aggregation, neuroinflammation, and age-related neuronal loss (Ramirez et al., 2025, Scheltens et al., 2021)

It can be given intravenously or intramuscularly, with dosing frequency adjusted based on the severity of deficiency and the patients response

Early events include mutation in tumor suppressive genes such as p53 (up to 64% of tumors) and p21 (up to 55% of tumors)

Nguyen HL, Linh HQ, Krupa P et al (2022) Amyloid dodecamer disrupts the neuronal membrane more strongly than the mature fibril: understanding the role of oligomers in neurotoxicity

Europe 4.4.3