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Together, these results indicate that specific deletion of Trkb in iSPNs results in GSTO2 upregulation, which, through its DHAR activity, leads to DA dysfunction in Trkb Penk -KO mice at the pre-symptomatic stage

ROS generation induced by HCV infection triggers anti-3-hydroxysterol 24-reductase (DHCR24) antibody production, suggesting that DHCR24 may be used as a prognostic biomarker for hepatitis C progression to hepatocellular carcinoma 56,97

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