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A vitamin B12 shortage can cause a variety of health issues, ranging from exhaustion to permanent neurological abnormalities

For instance, in LCSCs, ALDOA lactylation attenuates its binding with DDX17, enhancing the regulatory function of DDX17 in maintaining stemness and promoting tumorigenicity and progression of HCC

Those who maintain a vegan diet are also at high risk of developing a vitamin B12 deficiency since meats and other animal by-products are some of the best sources of B12

Moreover, HGF prevents NMDA-induced neuronal death in hippocampal neuron cultures in vitro by blocking pro-apoptotic caspase-3 activation and translocation of AIF into the nucleus (Ishihara et al., 2005)

Proteolytic activation of latent PPOs with trypsin has been reported for broad bean PPO 46 , paraguaya peach PPO 47 , spinach PPO 48 , loquat fruit PPO 49 , beet root PPO 19 , grape PPO 50 and apple PPO 21