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Similar content being viewed by others Introduction Reduced glutathione (GSH) provides the cellular first line of defense against oxidative stress-induced injury, which can be maintained by NADPH generated mainly via the pentose phosphate pathway and its rate-limiting enzyme, glucose-6-phosphate dehydrogenase (G6PD

Glutathione is a small protein molecule composed of 3 amino acids: cysteine, glutamate, and glycine called Glutathione precursors or building blocks

The rectangular boxes and ovals contain the acronyms of the substrates and enzymes, respectively

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