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Besides the aforementioned antigen multivalency, nanocarriers enable efficient co-delivery of antigen/adjuvant to secondary lymphoid organs 59 , exhibit size-dependent lymphatic trafficking and preferential uptake by antigen presenting cells (APCs), create depot effects for sustained immune stimulus, and facilitate antigen cross presentationenabling extracellular antigens to be presented via the MHC-I pathway for CD8 + T cell engagement 60 (Fig

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