US patent 0337024, Allison Coffin, Joseph Harding, Leen Kawas, Phillip Uribe, "Novel Lead Compound for Otoprotection: Targeting HGF Signaling with Dihexa", issued 2015-11-26 "Dihexa" (PDF)
Other groups found similar outcomes that linked the GPx3 locus to ALS but were also able to demonstrate that lower GPx3 levels strongly correlated with more advanced disease, in addition to showing significant motor deficits in a knockdown zebra fish model 21
doi:10.1074/jbc.M008212200
Urea and uric acid can safely diffuse into the blood and then be excreted in urine
In addition, inhalation of virus-like nanoparticles self-assembled from cowpea mosaic virus (CPMV) can be rapidly taken up and activated by neutrophils in the TME, and activated and tumor-infiltrating (N1) neutrophils significantly increased 24 hours after inhalation of eCPMV, ultimately delaying tumor progression and significantly prolonging survival (116)