Some patients report mild diarrhoea, nausea, or headache following administration, though these symptoms are usually transient
Current investigations continue to assess NNMT-associated enzymatic activity, NAD+-related signaling, and cellular energy metabolism behavior across different in vitro systems and analytical frameworks
Kannt A, Pfenninger A, Teichert L, Tnjes A, Dietrich A, Schn MR, Klting N, Blher M. Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance. Diabetologia. 2015 Apr;58(4):799-808. doi: 10.1007/s00125-014-3490-7. Epub 2015 Jan 18. PMID: 25596852; PMCID: PMC4351435
The kidneys help get rid of extra B12
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