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Biomedicine & Pharmacotherapy, p 116739 Gu S (2022) Glymphatic dysfunction induced oxidative stress and neuro-inflammation in major depression disorders

Protocol 3: metabolic health optimization Goal: Reduce liver fat, improve insulin sensitivity, address metabolic syndrome Tirzepatide approach: Standard escalation to 10 mg Produces moderate liver fat reduction Significant HbA1c improvements (if diabetic) Meaningful but not maximal metabolic improvements Retatrutide approach: Escalation to 8-12 mg 86% of patients achieved normal liver fat at 12 mg Superior metabolic marker improvements across all measures Glucagon component directly targets hepatic lipid metabolism If metabolic health is your primary goal rather than the number on the scale, the retatrutide dosage chart offers something tirzepatide fundamentally cannot: direct glucagon-mediated liver fat reduction

doi: 10.1016/j.bbi.2016.07.002 58 GaliciR.BoggsJ

J Psychopharmacol 31(9):11491165 Achtyes E et al (2020) Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression

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