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By combining three receptor activities into a single stable compound, Trinity-X provides a powerful research tool to investigate multi-pathway metabolic control, including satiety signaling, insulin secretion dynamics, and lipid breakdown mechanismswithout requiring separate agonists for each pathway
Fourteen reported subjective improvement, but there was no control group, no blinded assessment, no objective functional endpoint and no follow-up imaging endpoint [5]
In a phase II trial, adults with a BMI of 30 or 27 kg/m with comorbidities were randomized to receive efpeglenatide at doses of 4 mg weekly, 6 mg weekly, 6 mg biweekly, or 8 mg biweekly, or a placebo, all combined with a hypocaloric diet [17]
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