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From these results we can assume ozone therapy influenced positively the synthesis and release of cytokines (14,15) in such away that a change from Th2 to Th1 [IL-2, IFNg] pattern occurs, reducing the production of asthma mediators [IgE, HLA-DR, etc]

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117,118 Further investigations are encouraged to explore changes in downstream Wnt/-catenin gene expression to eventually develop potentially propitious pharmacological drugs for AVS