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More sensitive to subtle vision changes than standard acuity testing

Amo-Aparicio J, Daly J, Hjen JF, Dinarello CA (2023) Pharmacologic inhibition of NLRP3 reduces the levels of -synuclein and protects dopaminergic neurons in a model of Parkinsons disease

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The reason is entirely about gastrointestinal tolerability nausea, diarrhea, and vomiting were clearly dose-dependent and concentrated in the weeks right after each step-up