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The m6A RNA modification of HMGCS1 mediated by Mettl3, the inhibition of which alleviated ferroptosis of R28 cells and restored the visual function in rats, was viewed as a key regulator of RGC ferroptosis (101)

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Probenecid (Benemid) Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid

In addition, RSL3, another ferroptosis inducer, can covalently bind to selenocysteine at the active site of GPX4, thus directly inhibiting the phospholipid peroxidase activity of GPX4 [54]