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Previous reports of the surgeon general have established that nearly all habitual tobacco use begins during youth and young adulthood. Because the human brain is developing until about age 25, using substances at a young age can have lifelong consequences

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"Trends in smoking and quitting in China from 1993 to 2003: National Health Service Survey data"

Furthermore, the study also checked the influence of p H on SLT-associated microbial composition and observed that there was no significant effect of p H on the bacterial as well as fungal OTUs in the SLT (Supplementary Figure)