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Research in The Journal of Investigative Dermatology documented increased collagen I, II, and III synthesis in treated cells

Some may have mild side effects like pain at the injection site, headache, or dizziness

Anecdotal reports vary, but some individuals mention mild headaches, anxiety, or an overstimulated feeling

GIP is also implicated in nausea attenuation, which may be why GLP-1/GIP dual agonists like tirzepatide have a slightly better GI tolerability profile than pure GLP-1 agonists

Unlike some peptides that are immediately destroyed by stomach acid, research suggests the arginate salt formulation may maintain structural integrity long enough to pass through the stomach