When medications for weight management are used to augment lifestyle intervention, they offer a rational pathway for sustained weight loss because they result in more weight loss than can be achieved with lifestyle intervention alone
CagriSema, the cagrilintide and semaglutide combination, has been filed for FDA review, but filing is not approval
This phenomenon, sometimes called tolerance or tachyphylaxis, is not well-studied specifically for semaglutide, but it is reported frequently in practice
Retrieved May 6, 2025, from National Institutes of Health, Office of Dietary Supplements
In patients receiving cagrilintide 2.4 mg plus semaglutide, there was a mean body weight change from baseline of -17.1% compared to -9.8% with semaglutide alone