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Pollen glucans can also stimulate Toll-like receptors (TLRs) in phagocytes and dendritic cells (DCs), and they can contribute to mitochondrial dysfunctions that also lead to the overproduction of ROS (65)

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Additionally, metabolomic methodologies have the capacity to elucidate the underlying mechanisms of osteophyte formation in OA, revealing metabolic alterations associated with this pathological development, including changes in amino acids, sulfonic acids, glycerophospholipids, and fatty acyls [75]

Several studies have shown that iron is necessary for ferroptosis, and excessive iron deposition has been reported after TBI (Raz et al., 2011)

Currently, several therapeutic strategies are available for managing diabetic wounds, including aggressive debridement, surgical angiogenesis, antibacterial therapy, and bioengineered alternative tissue products 7,8