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Olefsky JM (2008) Fat talks, liver and muscle listen

This causes your skin to wrinkle and sag and your muscles, bones, and tendons to shrink, stiffen, and get weaker

Michell et al., 1999

PLoS ONE 9:e101815

Week 1: Dose: 50mcg Frequency: Once, on a night when you can sleep in the next morning Timing: 2-3 hours before intended sleep Purpose: Assess basic tolerance and response Week 2: Dose: 75-100mcg Frequency: 2-3 times during the week Timing: 1-2 hours before bed Purpose: Establish baseline effective dose During this assessment phase, track sleep quality subjectively and, if possible, with a wearable device that measures sleep stages