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222-224 Stress and anxiety appear to contribute to gut hypersensitivity via modulation of neural pain-processing pathways by glucocorticoid hormones, which are also called stress hormones. 225 Moreover, alterations of the microbiome have been observed in mood disorders, which frequently also present with IBS symptoms

This dual mechanism creates a robust antioxidant defense system that neutralizes reactive oxygen species before they can damage lipids, proteins, and DNA within the skin barrier

It is rare, but the immune-modulatory effects of weight loss and hormonal changes could theoretically trigger autoimmune responses in susceptible individuals

Wang et al., 2007

Keller J, Ringseis R, Koc A, Lukas I, Kluge H, Eder K