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Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy

[DOI] [PubMed] [Google Scholar] 55.Alshial EE, Abdulghaney MI, Wadan AS, et al

Preclinical studies have demonstrated that these derivatives retain potent DNA-damaging activity under hypoxic conditions while exhibiting reduced off-target effects in normoxic tissues

In contrast, single compounds like curcumin and resveratrol demonstrate well-defined antitumor immunomodulatory activities by modulating immune cell activation, functional maintenance, and cytokine production

Therefore, tenocytes were treated with H 2 O 2 (100 M, 4 h) to induce senescence, and dexamethasone (100 nM, 24 h pre-treatment +4 h treatment) was co-administered (Figure 6G)