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The female protocol represents a significant and timely expansion of the Blueprint project, given how underrepresented women have historically been in longevity and health optimisation research

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These findings suggest that cocaines effects on blood vessels in the brain differ as a function of sex and menstrual cycle phase, and imply that progesterone in women and testosterone in men may enhance cocaine-induced vasoconstriction, while estrogen in women may blunt cocaines vascular effects

Causes of small fiber neuropathy include idiopathic (30% of cases no identifiable cause), diabetes and pre-diabetes (impaired glucose tolerance), autoimmune diseases (Sjogrens syndrome, celiac disease, lupus), genetic causes (sodium channel gene mutations SCN9A, SCN10A), and sarcoidosis