First, it disrupts the process of melanin synthesis by inducing the release of high mobility group box 1 (HMGB1) protein, thus downregulating the melanin biosynthesis-related proteins: melanocyte-inducing transcription factor, tyrosinase, tyrosinase-related protein-1, tyrosinase-related protein-2, RAB27A and fascin actin-bundling protein 1 [17, 18]
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Inhibits melanin overproduction Glutathione shifts melanin production from dark pigment (eumelanin) toward lighter pigment (pheomelanin)
One of the mechanisms by which senescent cells escape from the immune response is made through the overexpression of the histocompatibility antigen alpha chain E (HLA-E) that bind to NKG2A, an inhibitor receptor expressed on Natural Killer cells (NK) 54 and CD8 + T cells, leading to the inhibition of SnCs recognition
Eur J Pharmacol 685:5969 Harhai M, Harsing LG (2022) An overview of glycine transporter subtype 1 inhibitors under preclinical and clinical evaluation for the treatment of alcohol abuse
