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Although TZDs can increase body weight, weight gain mostly occurs in subcutaneous fat, while visceral fat, which is closely related to metabolic disorders, does not increase or even decreases

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It can make cells act younger

Among the six animal models of neurodegenerative disorder described above treatments with different class of HDAC inhibitors shows beneficial effect of HDAC inhibitors in improving neurodegenerative conditions by improving survival of neurons and preventing neuronal death through different mechanism ( Table 2 )