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Signaling properties of structurally diverse kappa opioid receptor ligands: toward in vitro models of in vivo responses

Therefore the overall impact on fertility that ROS has is not a matter of if it is there or not (as mentioned earlier, some oxidative stress is required for various reproductive physiological functions), but when levels of ROS are too high (or antioxidant levels are too low) it becomes pathological to sperm and the ability to get pregnant

Meissner et al., 2008), the aforementioned observation of dynamic Sox2 enhancer methylation awaits to be confirmed in vivo