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This is one of the largest studies to date to assess the relationship of tobacco smoke exposure, as measured objectively by serum cotinine levels, with rhinitis in a community-based population of 1,315 children

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Previous studies have observed that smoking duration has the greatest influence on COPD risk and this also occurs in other diseases such as lung cancer810,14,15 and cardiovascular disease.24 Thus, people who smoke with a lower intensity for a longer period of time have a higher risk of lung cancer than those who smoke with a higher intensity in a shorter period.8 In relation to COPD, this aspect has not been as extensively studied as in lung cancer

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