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A deficiency can cause a wide range of symptoms, including fatigue, weakness, memory problems, and anemia

The other consistent context in the preclinical literature is a metabolic environment the mouse studies pair the compound with diet/energy-balance conditions rather than testing it in isolation

According to the NHS, a lack of B12 may lead to anaemia, weakness, and even memory problems

Individuals with methylation issues, such as those with MTHFR variants, might respond differently to NNMT inhibition

Supplementation is unnecessary if parenteral therapy repletes serum levels, but individual assessment is advised