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This 46 difference means a 10mg oral dose delivers roughly the same systemic exposure as a 2mg injectable dose

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Where indicated, HFF-1-containing media were also incubated with a different treatment of either 10 or 30 mM GSH, or 4 g/mL amikacin alone, or a combination of 10 mM GSH + 4 g/mL amikacin, either in the presence or absence of bacteria

Hoboken: CRC Press

Students designing follow-on experiments often start with these signaling maps to frame their hypotheses