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Since the cuprizone regimen was several times higher than those regularly used in cuprizone studies, we used simple tests to determine animal responsiveness and impairment

This dose-tolerability relationship provides useful guidance for clinical protocol development

(PubMed) Goodman M, Bostick RM, Kucuk O, Jones DP

10.3748/wjg.v24.i48.5462 [DOI] [PMC free article] [PubMed] [Google Scholar] Duzel A., Vlainic J., Antunovic M., Malekinusic D., Vrdoljak B., Samara M., et al

Conclusion: AOD 9604 dose dependently increases bone density, improves bone microstructure, enhances bone strength, and reverses bone metabolism imbalance in postmenopausal osteoporotic rats