Concomitant use of hydrocodone bitartrate and acetaminophen tablets with a CYP3A4 inhibitor, such as macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole), and protease inhibitors (e.g., ritonavir), may increase plasma concentrations of hydrocodone bitartrate and acetaminophen tablets and prolong opioid adverse reactions, and which may cause potentially fatal respiratory depression (see WARNINGS), particularly when an inhibitor is added after a stable dose of hydrocodone bitartrate and acetaminophen tablets is achieved
Any extra-pharmaceutical human use falls outside the legitimate product scope, and lot-to-lot traceability via certified COA constitutes the first regulatory defense line for purchasing laboratories
Call 911 immediately if you see: confusion, collapse, seizures, very hot skin, or stopped sweating
PMC 1204285
*Correction*: since publishing this article, people have pointed me to grey market sources of klotho that are research grade
