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These studies will be critical for understanding the research utility of this pathway and identifying optimal applications for future investigational development

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The research rationale established by NNMT-knockdown studies in diet-induced-obese mice is that inhibiting NNMT preserves intracellular NAD+ and SAM levels, which in adipocyte (fat-cell) models has been shown to suppress de novo lipogenesis

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Evidence type: Human RCT | Observational | Animal | In vitro | Regulatory Mechanism of Action AOD-9604 mimics the fat-metabolizing region of growth hormone