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analogs or growth factor mimics of the present invention may also be represented as comprised of four elements joined by covalent peptide or reduced peptide bonds, as follows: I an acid such as heptanoic, hexanoic, pentanoic, butyric, proprionic, acetic, benzoic, or substituted benzoic acid, and isoforms thereof

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Testing Levels: Soluble -klotho can be measured in serum using commercial ELISA kits (e.g., IBL International JP27998)

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