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Walker RF, et al

If you see blood enter the syringe this means you hit a blood vessel and you need to pull out and start over

Recombinant fibroblast growth factor 21 can activate fibroblast growth factor receptor 1, which increases its interaction with Keap1, a repressor of Nrf2, thus decreasing Keap1-Nrf2 interaction, resulting in Nrf2 secretion [107]