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Dec 15 2020;21(24)doi:10.3390/ijms21249554 Dumitrescu R, Mehedintu C, Briceag I, Purcarea VL, Hudita D

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Combination Therapy (Alpha-Blocker + 5-ARI) (Example: Jalyn ) Benefit: Immediate symptom relief + long-term reduction in prostate size Best for: Men with moderate-to-severe symptoms and large prostates Data from MTOPS Trial: Combination therapy delayed progression more than either drug alone Risk of progression reduced by 66% with combination therapy Also led to greater improvement in symptom scores and lower need for surgery 4