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GLS1 is the rate-limiting enzyme responsible for the breakdown of Gln

Brain swelling occurs because fluid builds up in or around the brain tissue, which can create dangerous pressure inside the skull

Methionine is activated by adenosine triphosphate leading to the generation of S-adenosylmethionine (SAM), which is a ubiquitous methyl group donor as it donates methyl groups in transmethylation reactions involved in the synthesis or activation of a wide range of bioactive compounds such as DNA, proteins, neurotransmitters, and membrane phospholipids, all of which are regulators of important physiological processes (Reference Bailey, Stover and McNulty5)

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