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Epub 2010 Oct 13

Using the amount of dGSH adduct of acetaminophen formed under the same conditions as a reference, the adduct formation rates of anethole and pulegone correlated well with their toxicity profiles while those of eugenol and nordihydroguaiaretic acid did not

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The composition and volume of melanin within an organisms body are contingent upon several factors, including the differentiated state of melanocytes, the population of melanocytes, the extent of melanogenesis, dendritic characteristics, and various environmental elements such as the local tissue microenvironment, vascular supply, exposure to UV radiation, and ionizing radiation 36