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While direct evidence for NET-driven pathology in PCOS remains limited, mechanistic insights from related inflammatory and metabolic diseases indicate that NET-associated pathways can amplify thrombo-inflammatory signaling, endothelial dysfunction, and tissue injury

Zammit, R

Curcumin attenuates renal interstitial fibrosis of obstructive nephropathy by suppressing epithelial-mesenchymal transition through inhibition of the TLR4/NF-B and PI3K/AKT signalling pathways

This can lead to fine lines, stubborn body fat, and a general dip in energy

The anti-proliferation mechanism is somewhat complicated because p38MAPK is known to negatively regulate cyclin D1 [183]