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Although a plethora of tumor cell mechanosensors have been identified, including focal adhesions, ion channels, actin cytoskeleton, nuclear proteins, and transcription factors, more research is needed to uncover how breast cancer cells convert biophysical signals into biochemical cues to mediate short- and long-term mechanoresponses ( Table 5 )
This pulsatile GH output then promotes hepatic and peripheral IGF1 production, supporting anabolic processes such as protein synthesis, lipolysis, and tissue repair
