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Patients should be provided with a letter from their healthcare provider or pharmacy documenting the medical necessity of carrying injection supplies

Interestingly, male patients with inflammatory bowel disease (IBD) exhibit downregulated GPER expression in intestinal tissue, accompanied by elevated proinflammatory cytokine levels, whereas female patients are more likely to benefit from GPER agonists, which increase anti-inflammatory signaling and reduce intestinal inflammation [76]

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