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Asthma exacerbations are among the most documented sulfite allergies, but this has largely been studied in the context of reactions to wine

This limits cumulative exposure while allowing the body extended periods without receptor modulation

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Clinical manifestations of NMS include hyperpyrexia, muscle rigidity, altered mental status, and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmia)

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