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These impacts are mainly facilitated by IGF-1 generation in both the liver and peripheral tissues

Epub 2011 Apr 8

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Under these uncontrolled conditions, the concentrations of ROS exceed the capacity of local antioxidant molecules neutralize them (112, 115, 150), resulting in a buildup of ROS O and H 2 O 2 , and also malondialdehyde, at the site of the ovary and in follicular fluid and peritoneal fluid (103, 105, 106, 108, 111, 112)