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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

Complete resolution of symptoms after one treatment was reported in 10 out of 12 patients, who rated their success at 100%

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They bypass the gastrointestinal tract and deliver the vitamin directly into the bloodstream